{"id":170,"date":"2015-08-19T11:50:54","date_gmt":"2015-08-19T10:50:54","guid":{"rendered":"https:\/\/charlesnduka.co.uk\/plastic-surgery\/?page_id=170"},"modified":"2015-08-19T11:50:54","modified_gmt":"2015-08-19T10:50:54","slug":"comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures","status":"publish","type":"page","link":"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/","title":{"rendered":"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures."},"content":{"rendered":"<p><em>Puttick MI, Scott-Coombes DM, Dye J, Nduka CC, Menzies- Gow NM, Mansfield AO, Darzi A. Surg Endosc. 1999 Jun;13(6):572-5.<\/em><\/p>\n<h2>Abstract<\/h2>\n<h3>Background<\/h3>\n<p>Prolonged and complex laparoscopic procedures expose patients to large volumes of cool insufflation gas. The aim of this study was to compare the effects of a conventional room temperature carbon dioxide (CO2) pneumoperitoneum with those of a body temperature pneumoperitoneum.<\/p>\n<h3>Methods<\/h3>\n<p>Patients were randomized to undergo laparoscopic cholecystectomy with a CO2 pneumoperitoneum warmed to either body temperature (n = 15) or room temperature (n = 15). The physiologic and immunologic effects of warming the gas were examined by measuring peroperative core and intraperitoneal temperatures, peritoneal fluid cytokine concentrations, and postoperative pain.<\/p>\n<h3>Results<\/h3>\n<p>The mean duration of surgery was 32 min in both groups. Core temperature was reduced in the room temperature group (mean, 0.42 degrees C; p &lt; 0.05). No reduction in temperature occurred when the gas was warmed. Greater levels of cytokines were detected in peritoneal fluid from the room temperature insufflation group tumor necrosis factor alpha (TNF-alpha): mean, 10.9 pg\/ml vs. 0.42, p &lt; 0.05; interleukin 1 beta (IL-1beta): mean, 44.8 pg\/ml vs. 15.5, p &lt; 0.05; and IL-6: mean, 60.4 ng\/ml vs. 47.2. There was no difference in postoperative pain scores or analgesia consumption between the two groups.<\/p>\n<h3>Conclusions<\/h3>\n<p>The authors conclude that intraoperative cooling can be prevented by warming the insufflation gas, even in short laparoscopic procedures. In addition, warming the insufflation gas leads to a reduced postoperative intraperitoneal cytokine response.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Puttick MI, Scott-Coombes DM, Dye J, Nduka CC, Menzies- Gow NM, Mansfield AO, Darzi A. Surg Endosc. 1999 Jun;13(6):572-5. Abstract Background Prolonged and complex laparoscopic procedures expose patients to large volumes of cool insufflation gas. The aim of this study was to compare the effects of a conventional room temperature carbon dioxide (CO2) pneumoperitoneum with [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":38,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-170","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures. | Charles Nduka - Plastic Surgery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures. | Charles Nduka - Plastic Surgery\" \/>\n<meta property=\"og:description\" content=\"Puttick MI, Scott-Coombes DM, Dye J, Nduka CC, Menzies- Gow NM, Mansfield AO, Darzi A. Surg Endosc. 1999 Jun;13(6):572-5. Abstract Background Prolonged and complex laparoscopic procedures expose patients to large volumes of cool insufflation gas. The aim of this study was to compare the effects of a conventional room temperature carbon dioxide (CO2) pneumoperitoneum with [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/\" \/>\n<meta property=\"og:site_name\" content=\"Charles Nduka - Plastic Surgery\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/\",\"url\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/\",\"name\":\"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures. | Charles Nduka - Plastic Surgery\",\"isPartOf\":{\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#website\"},\"datePublished\":\"2015-08-19T10:50:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#website\",\"url\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/\",\"name\":\"Charles Nduka - Plastic Surgery\",\"description\":\"Consultant Plastic, Reconstructive &amp; Cosmetic Surgeon\",\"publisher\":{\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#organization\",\"name\":\"Charles Nduka - Plastic Surgery\",\"url\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/wp-content\/uploads\/2024\/04\/logo.jpg\",\"contentUrl\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/wp-content\/uploads\/2024\/04\/logo.jpg\",\"width\":350,\"height\":100,\"caption\":\"Charles Nduka - Plastic Surgery\"},\"image\":{\"@id\":\"https:\/\/charlesnduka.co.uk\/plastic-surgery\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures. | Charles Nduka - Plastic Surgery","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/charlesnduka.co.uk\/plastic-surgery\/research\/comparison-of-immunologic-and-physiologic-effects-of-co2-pneumoperitoneum-at-room-and-body-temperatures\/","og_locale":"en_GB","og_type":"article","og_title":"Comparison of immunologic and physiologic effects of CO2 pneumoperitoneum at room and body temperatures. | Charles Nduka - Plastic Surgery","og_description":"Puttick MI, Scott-Coombes DM, Dye J, Nduka CC, Menzies- Gow NM, Mansfield AO, Darzi A. 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